Functional lung imaging in radiation therapy for lung cancer: A systematic review and meta-analysis

Abstract

Rationale: Advanced imaging techniques allow functional information to be derived and integrated into treatment planning. Methods: A systematic review was conducted with the primary objective to evaluate the ability of functional lung imaging to predict risk of radiation pneumonitis. Secondary objectives were to evaluate dose–response relationships on post treatment functional imaging and assess the utility in including functional lung information into treatment planning. A structured search for publications was performed following PRISMA guidelines and registered on PROSPERO. Results: 814 articles were screened against review criteria and 114 publications met criteria. Methods of identifyin..